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Current Status of Decompressive Craniectomy Following Traumatic Brain Injury



Current status of decompressive craniectomy following traumatic brain injury

Angelos G. Kolias, Clinical Lecturer in Neurosurgery, Addenbrooke’s Hospital & University of Cambridge, Cambridge, UK angeloskolias@gmail.com
Peter J. Hutchinson,  Professor of Neurosurgery,  Addenbrooke’s Hospital & University of Cambridge, Cambridge, UK pjah2@cam.ac.uk
Franco Servadei, Professor of Neurosurgery, University Hospitals of Parma and Reggio Emilia & University of Parma, Italy francoservadei@libero.it

Decompressive craniectomy (DC) refers to the practice of removing a large bone flap and opening the underlying dura in order to control brain swelling and raised intracranial pressure (ICP).1 The two most frequent indications for a DC are traumatic brain injury (TBI) and ischaemic stroke. This newsletter article will focus on the use of supratentorial DC following TBI.

Definitions

Hemi-craniectomy or unilateral DC refers to the removal of a large fronto-temporo-parietal bone flap, whereas bifrontal DC refers to the removal of a bone flap extending from the floor of the anterior cranial fossa anteriorly to the coronal suture posteriorly and to the middle cranial fossa floor bilaterally. Wide opening of the dura is a necessary part of the procedure.2

Subtypes of TBI where DC IS used

  • A DC is most frequently undertaken in comatose patients with an acute subdural haematoma (ASDH) and associated brain swelling in the early phase after injury.3 In this group of patients, the ASDH is evacuated and a large bone flap is left out either because the brain is bulging beyond the inner table of the skull or because increasing brain swelling (e.g. in a patient with coexisting contusions) is anticipated in the post-operative period. This type of DC is termed primary and is most frequently a unilateral hemi-craniectomy.
  • A DC can also be undertaken in comatose patients who have contusions (usually fronto-temporal) with substantial mass effect. This usually manifests as midline shift (> 5 mm) and/or uncal herniation in the case of predominantly unilateral contusions or obliterated basal cisterns in the case of bilateral contusions. Such patients may initially receive ICP monitoring (if available) and proceed to a DC later on, if their ICP becomes difficult to control. This type of DC is termed secondary and can be unilateral (for predominantly unilateral pathology) or bifrontal (for predominantly bilateral pathology). Alternatively, patients with severe mass effect and clinical signs of herniation (e.g. anisocoria) may receive a DC early on after their injury without monitoring their ICP initially.
  • Patients who have had a craniotomy (i.e. bone flap replaced at the end of procedure) for evacuation of an intracranial haematoma (extradural, subdural or intracerebral) in the early phase after their injury, occasionally undergo a DC later on if their ICP becomes difficult to control or if they deteriorate neurologically with radiological evidence of increasing mass effect. This usually occurs in patients with coexisting contusions which are blossoming. 
  • Other less frequent indications include: blunt TBI with diffuse brain swelling without any significant haematomas / contusions; gunshot wound with gross haemorrhage and swelling; severe blast injury with gross swelling.

Overall, a primary DC undertaken at the same time as evacuating a haematoma is the most frequent indication.4 A secondary DC, undertaken usually after a period of ICP monitoring due to difficulties with controlling the ICP and/or clinico-radiological deterioration, is a less frequent indication.

Evidence base

Several uncontrolled studies presenting encouraging results with the use of DC have been published, especially so since the 1990s. However, uncontrolled studies suffer from several types of bias, and this was the motivation for the launch of two investigator-initiated multi-centre randomised trials in early 2000s: the DECRA trial and the RESCUEicp trial.5,6 A third multi-centre randomised trial (RESCUE-ASDH) was launched in 2014.7

DECRA trial

The DECRA study was conducted between 2002 and 2010 in Australia, New Zealand and Saudi Arabia and focused on the role of early secondary DC for patients with severe diffuse TBI and mild-to-moderate intracranial hypertension.8 In this study, 155 patients were enrolled within the first 72 h following TBI if their ICP exceeded 20 mmHg for >15 min (continuously or intermittently) within a 1-h period, and if they did not respond to optimised first-tier ICP-lowering interventions (e.g. sedation, normocapnia, osmotherapy etc). The two arms of the trial were bifrontal DC and standard medical management or standard medical management alone. Patients in the surgical arm had better ICP control, received fewer interventions for raised ICP, and had a reduced length of stay in the intensive care unit (ICU). However, the investigators observed a higher rate of unfavourable outcomes (death, vegetative state, severe disability) in surgical patients at 6 months (70% versus 51%; OR 2.21; 95% CI 1.14–4.26; p=0.02). The mortality was similar in both arms (19% in surgical vs. 18% in medical patients). Nevertheless, 27% of patients in the surgical arm had bilaterally unreactive pupils compared with only 12% in the medical arm. A post hoc adjustment for pupil reactivity at baseline, which was necessary as pupil reactivity is known to be a major prognostic indicator of outcome following TBI, revealed that the rate of unfavourable outcome was not significantly different between the two arms (adjusted OR 1.90; 95% CI 0.95–3.79). Overall, the DECRA study indicated that early neuro-protective bifrontal DC for mild-to-moderate intracranial hypertension is not superior to medical management for patients with diffuse TBI.

RESCUEicp TRIAL

Contrary to the DECRA study, the RESCUEicp trial examined the effectiveness of DC (bifrontal or unilateral) as a last-tier treatment for patients with severe, sustained and refractory post-traumatic intracranial hypertension.9 Patients were randomised to DC or continuing medical therapy if their ICP exceeded 25 mmHg for at least 1 h and could not be controlled by first-tier and second-tier ICP-lowering interventions. Overall, 408 patients were enrolled from 52 centres in 20 countries. At 6 months, DC resulted in mortality that was 22% lower than that with medical management. However, DC was also associated with higher rates of vegetative state, lower severe disability (dependent on others for care), and upper severe disability (independent at home) than medical management. The rates of moderate disability and good recovery with surgery were similar to those with medical management. In a prespecified sensitivity analysis, favourable outcomes (prespecified as upper severe disability, moderate disability and good recovery) occurred in 42.8% of surgical patients and 34.6% of medical patients (p=0.12). At 12 months, the mortality difference did not change but surgical patients improved further; as a result favourable outcomes (upper severe disability or better) were observed in 45.4% of the surgical patients and 32.4% of medical patients (p=0.01).
The RESCUEicp trial had a number of important differences from DECRA: surgical technique (bifrontal or unilateral DC versus bifrontal DC only); ICP threshold (25 mmHg versus 20 mmHg); duration of refractory intracranial hypertension (at least 1 h versus 15 min); timing of randomisation (any time when inclusion criteria are met versus within 72 h after TBI only); inclusion of patients with evacuated or non-evacuated intracranial haematomas (allowed in RESCUEicp but not in DECRA). These differences explain the contrasting findings of the two trials. However, both trials are valuable and complement each other as one looked at secondary DC as a neuro-protective measure (DECRA), whereas the other examined secondary DC as a last-tier intervention (RESCUEicp).

RESCUE-ASDH

Acute subdural haematomas are still considered the most lethal subtype of TBI and they are often associated with contusions and brain swelling. However, there is a paucity of high-quality evidence in the literature regarding the best surgical strategy (primary DC or craniotomy) for these patients and there is considerable variation in practice. For example, a recent international survey found that a higher proportion of neurosurgeons from other European countries (48/110; 44 %) as compared with UK/Irish neurosurgeons (29/138; 21 %) use primary DC in more than half of ASDH cases (p<0.001).10
The RESCUE-ASDH study was funded by the UK National Institute for Health Research (NIHR) and was launched in 2014 in order to compare primary DC (bone flap left out) with craniotomy (bone flap replaced) for severe TBI patients undergoing evacuation of an ASDH.7
The criteria which are being used to determine eligibility of individual patients are:
Inclusion criteria:

  • Adult head-injured patients (>16 years)
  • ASDH on CT*
  • The admitting neurosurgeon feels that the haematoma needs to be evacuated either by a craniotomy or DC (bone flap at least 11 cm in both instances)*

* Patients with additional lesions (e.g. intracerebral haemorrhage, contusions) can be included
Exclusion criteria:

  • Bilateral ASDHs both requiring evacuation
  • Previous enrolment in RESCUE-ASDH study
  • Severe pre-existing physical or mental disability or severe co-morbidity which would lead to a poor outcome even if the patient made a full recovery from the head injury.

Eligible patients are randomised intra-operatively after evacuating the ASDH. Patients with significant brain swelling preventing safe replacement of the bone flap are not suitable for randomisation and are being followed-up in the context of an observational cohort. The primary endpoint is functional outcome assessed with the extended Glasgow Outcome Scale (GOSE) at 12-months post-injury.
Almost 140 patients have been randomised in the trial so far. The trial is in the process of roll-out to several countries worldwide. Clinicians interested to collaborate are encouraged to visit http://www.rescueasdh.org/contact-us for further information.

ADDITIONAL CONSIDERATIONS

  • About 90% of trauma-related deaths occur in low- and middle-income countries (LMICs). However, less than 10% of the RESCUEicp patient population was enrolled in LMICs (36/408 patients – 6 countries), whereas all patients in the DECRA study were from high-income countries (HICs).  We are hoping that more patients from LMICs will be enrolled in the RESCUE-ASDH trial but this fact raises some important questions:
    • Is it possible to extrapolate the results from studies taking place in HICs (where pre-hospital, acute neurosurgical, and post-acute care are generally delivered in a more systematic way) to the patients treated in LMICs?
    • Is it possible for neurosurgeons working in LMICs to follow recommendations derived from the DECRA and RESCUEicp studies, given that ICP monitoring may not be available in their daily practice?

However, the burden of TBI is much higher in LMICs and patients have to be treated for TBI despite the absence of evidence directly applicable to these countries. These are issues that, we feel, are worthy of attention and further study as part of efforts to improve global neurotrauma care.11

  • More attention needs to be paid to the issue of cranial reconstruction (cranioplasty) following DC. There is a suggestion from small, uncontrolled studies that earlier cranioplasty (within 3 months from DC) may facilitate rehabilitation and may even independently improve the long-term outcome.12 From the surgical viewpoint, the tissue planes seem to more favourable when a cranioplasty is undertaken early. However, there are concerns that the rate of infection may be higher with earlier cranioplasty, and infection remains a frequent complication (10-20%) of this procedure.13 Additionally, a number of different materials are available (e.g. titanium, PEEK, hydroxyapatite, the patient’s own bone flap etc) but uncertainty remains as to whether any one of them is associated with better outcomes. Moreover, cranioplasty-related costs differ between different materials and this is an important consideration for LMICs but also several HICs with state-funded healthcare systems.
  • The use of floating or hinged bone flaps is a potential decompressive method for TBI.14 The opening of basal cisterns has also been suggested as a surgical manoeuvre for reducing raised ICP.15 However, evidence regarding the effectiveness of these techniques is limited. Nevertheless, floating or hinged bone flaps are likely to have the potential to control moderate swelling, whilst at the same time obviate the need for a subsequent cranioplasty. This would be an important consideration in resource-limited settings. Hence, we feel that these techniques should be evaluated prospectively with controlled studies, as if they are proven to be beneficial, they could advance the care of patients in LMICs.

CONCLUSIONS

Several TBI subtypes associated with brain swelling and/or raised intracranial pressure can be managed with a DC. However, on the basis of evidence from multi-centre clinical trials, we can conclude that:

  • early neuro-protective bifrontal DC for mild-to-moderate intracranial hypertension is not superior to medical management for patients with diffuse TBI and
  • unilateral of bifrontal DC used as a last-tier therapy for patients with severe, sustained and refractory post-traumatic intracranial hypertension leads to a substantial mortality reduction but increases disability (both lower and upper severe disability) compared to medical management.

The RESCUE-ASDH trial is currently open and aims to define the role of primary DC for patients with acute subdural haematomas and swelling. The global neurosurgical community needs to consider the role of DC, cranioplasty and other decompressive procedures (e.g. floating or hinge craniotomy) not just in HICs but also, and perhaps more importantly, in LMICs due to a much greater TBI burden.

References

  1. Kolias AG, Kirkpatrick PJ, Hutchinson PJ. Decompressive craniectomy: past, present and future. Nat Rev Neurol. 2013;9(7):405-415. doi:10.1038/nrneurol.2013.106.
  2. Timofeev I, Santarius T, Kolias AG, Hutchinson PJA. Decompressive craniectomy - operative technique and perioperative care. Adv Tech Stand Neurosurg. 2012;38:115-136. doi:10.1007/978-3-7091-0676-1_6.
  3. Compagnone C, Murray GD, Teasdale GM, et al. The management of patients with intradural post-traumatic mass lesions: a multicenter survey of current approaches to surgical management in 729 patients coordinated by the European Brain Injury Consortium. Neurosurgery. 2005;57(6):232-40-1. doi:10.1227/01.neu.0000279218.53504.fe.
  4. Kramer AH, Deis N, Ruddell S, et al. Decompressive Craniectomy in Patients with Traumatic Brain Injury: Are the Usual Indications Congruent with Those Evaluated in Clinical Trials? Neurocrit Care. January 2016. doi:10.1007/s12028-015-0232-8.
  5. Cooper DJ, Rosenfeld J V, Murray L, et al. Early decompressive craniectomy for patients with severe traumatic brain injury and refractory intracranial hypertension--a pilot randomized trial. J Crit Care. 2008;23(3):387-393. doi:10.1016/j.jcrc.2007.05.002.
  6. Hutchinson PJ, Corteen E, Czosnyka M, et al. Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com). Acta Neurochir Suppl. 2006;96:17-20. http://www.ncbi.nlm.nih.gov/pubmed/16671415. Accessed November 29, 2015.
  7. Kolias AG, Adams H, Timofeev I, et al. Decompressive craniectomy following traumatic brain injury: developing the evidence base. Br J Neurosurg. 2016;30(2):246-250. doi:10.3109/02688697.2016.1159655.
  8. Cooper DJ, Rosenfeld J V., Murray L, et al. Decompressive Craniectomy in Diffuse Traumatic Brain Injury. N Engl J Med. 2011;364(16):1493-1502. doi:10.1056/NEJMoa1102077.
  9. Hutchinson PJ, Kolias AG, Timofeev IS, et al. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension. N Engl J Med. 2016;375(12):1119-1130. doi:10.1056/NEJMoa1605215.
  10. Kolias AG, Belli A, Li LM, et al. Primary decompressive craniectomy for acute subdural haematomas: results of an international survey. Acta Neurochir (Wien). 2012;154(9):1563-1565. doi:10.1007/s00701-012-1349-6.
  11. Park KB, Johnson WD, Dempsey RJ. Global Neurosurgery: The Unmet Need. World Neurosurg. 2016;88:32-35. doi:10.1016/j.wneu.2015.12.048.
  12. Bender A, Heulin S, Röhrer S, et al. Early cranioplasty may improve outcome in neurological patients with decompressive craniectomy. Brain Inj. 2013;27(9):1073-1079. doi:10.3109/02699052.2013.794972.
  13. Honeybul S, Ho KM. Long-term complications of decompressive craniectomy for head injury. J Neurotrauma. 2011;28(6):929-935. doi:10.1089/neu.2010.1612.
  14. Schmidt JH, Reyes BJ, Fischer R, Flaherty SK. Use of hinge craniotomy for cerebral decompression. Technical note. J Neurosurg. 2007;107(3):678-682. doi:10.3171/JNS-07/09/0678.
  15. Cherian I, Bernardo A, Grasso G. Cisternostomy for Traumatic Brain Injury: Pathophysiologic Mechanisms and Surgical Technical Notes. World Neurosurg. 2016;89:51-57. doi:10.1016/j.wneu.2016.01.072.
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